Transhumanism discussions so frequently miss the point by a long shot. It's supposed to be "trans"-human.  Think outside the box:  move to the Kuiper Belt, swim in liquid methane on Titan, explore high pressure societies of cloud based life on Jupiter.

Some would say even those ideas aren't grand enough, we will shatter spacetime and explore 11-dimensional subdomains of gluon interaction space, trasnform into intergalactic plasma waves.  Or with a nod to Charlie Stross:  become multi-corporeal and send your mind into a school of giant squid (swimming in methane lakes on Titan).